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在整个该感染流行地区罗阿丝虫微丝蚴血症的患病率。

Prevalences of Loa loa microfilaraemia throughout the area endemic for the infection.

作者信息

Boussinesq M, Gardon J

机构信息

ORSTOM, Paris, France.

出版信息

Ann Trop Med Parasitol. 1997 Sep;91(6):573-89. doi: 10.1080/00034989760671.

Abstract

Several cases of encephalopathy recorded in Cameroon since 1991 were in patients with very high, coincident, Loa loa microfilaraemias who had been treated with ivermectin for onchocerciasis. There was thus an urgent need to identify those areas where loiasis is hyperendemic, and where specific monitoring procedures should be developed if large-scale ivermectin treatment of onchocerciasis is to be implemented. In the present review, the available data on Loa endemicity are detailed and maps showing the prevalence of Loa microfilaraemia throughout the area endemic for the infection are presented. By superimposing these maps on those which show where onchocerciasis is meso- or hyper-endemic, it is now possible to identify several areas, in south-eastern Nigeria, southern and central Cameroon, the south of the Central African Republic, Equatorial Guinea, Gabon, and the north and west of the Democratic Republic of the Congo (ex-Zaire), where ivermectin treatment, although indicated, is most likely to lead to adverse reactions because of L. loa infections. Additional surveys, to delineate the areas highly infected with L. loa more accurately, are required.

摘要

自1991年以来,喀麦隆记录的几例脑病病例均发生在同时患有极高罗阿丝虫微丝蚴血症的患者身上,这些患者因盘尾丝虫病接受了伊维菌素治疗。因此,迫切需要确定罗阿丝虫病高度流行的地区,以及如果要大规模实施伊维菌素治疗盘尾丝虫病,应制定特定监测程序的地区。在本综述中,详细介绍了关于罗阿丝虫病流行情况的现有数据,并展示了整个该感染流行地区罗阿丝虫微丝蚴血症患病率的地图。通过将这些地图叠加在显示盘尾丝虫病为中度或高度流行的地图上,现在可以确定尼日利亚东南部、喀麦隆南部和中部、中非共和国南部、赤道几内亚、加蓬以及刚果民主共和国(前扎伊尔)北部和西部的几个地区,在这些地区,尽管伊维菌素治疗有指征,但由于罗阿丝虫感染,很可能会导致不良反应。需要进行更多调查,以更准确地划定罗阿丝虫高度感染的地区。

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