Sebastián-Gámbaro M A, Lirón-Hernández F J, Fuentes-Arderiu X
Servei de Bioquímica Clínica, Ciutat Sanitària i Universitària de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
Eur J Clin Chem Clin Biochem. 1997 Nov;35(11):845-52.
Different results are usually observed when a quantity is measured in different specimens from the same individual obtained over a time span. For an individual, this variation is due to the imprecision of the measurement procedure, that is to say the metrological variability, as well as to the rhythmic and random fluctuations of the quantity value around a virtual homeostatic set point, that is to say the intra-individual biological variability. On the other hand, when studying the intra-individual biological variation of a quantity a mean value, the virtual homeostatic set point, is estimated for each individual participating in the study. The variation among these mean values is due to the inter-individual biological variability.
当在一段时间内从同一个体获取的不同样本中测量某一量值时,通常会观察到不同的结果。对于个体而言,这种变化是由于测量程序的不精确性,即计量变异性,以及量值围绕虚拟稳态设定点的节律性和随机性波动,即个体内生物变异性。另一方面,在研究某一量值的个体内生物变异时,会为参与研究的每个个体估计一个平均值,即虚拟稳态设定点。这些平均值之间的差异是由于个体间生物变异性。