Fraser C G, Harris E K
Department of Biochemical Medicine, Ninewells Hospital and Medical School, Dundee, Scotland.
Crit Rev Clin Lab Sci. 1989;27(5):409-37. doi: 10.3109/10408368909106595.
Most clinical chemical analytes vary in a random manner around a homeostatic set point. Replicate analyses of a series of specimens collected from a group of subjects allows estimation of analytical, within and between subject components of variation. The preferred experimental procedures and statistical methods for evaluation of data and analysis of variance are described; a detailed example is provided in the Appendix. The many uses of data on biological variation in clinical chemistry are reviewed, including setting analytical goals, deciding the significance of changes in serial results from an individual, evaluating the utility of conventional population-based reference values in patient management, and other applications.
大多数临床化学分析物围绕稳态设定点呈随机变化。对从一组受试者采集的一系列标本进行重复分析，可估计分析变异、个体内变异和个体间变异的组成部分。文中描述了评估数据和方差分析的首选实验程序和统计方法；附录中提供了详细示例。本文综述了临床化学中生物变异数据的多种用途，包括设定分析目标、判断个体连续结果变化的显著性、评估基于传统总体的参考值在患者管理中的效用以及其他应用。
