Mozdzanowska K, Furchner M, Maiese K, Gerhard W
Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Virology. 1997 Dec 8;239(1):217-25. doi: 10.1006/viro.1997.8882.
Recovery from influenza virus infection is dependent on T cell functions which can be provided either by CD8 or CD4 T cells. To identity the functions involved in recovery promoted by CD4 T cells, we have studied the course of the infection in B-cell deficient micro MT mice which had been depleted of CD8 T cells by antibody treatment. Upon infection with PR8 [A/PR/8/34(H1N1)], such B- and CD8 T cell-deficient mice mounted strong CD4 T cell responses that were comparable in size and cytokine secretion to those seen in intact mice. Yet, these B- and CD8 T cell-deficient mice could not clear the infection, in contrast to (CD8-depleted) mice containing both B- and CD4 T cells. These findings indicate that the promotion of the T-dependent antibody response is an indispensable component in the CD4 T cell-dependent recovery process.
从流感病毒感染中恢复取决于T细胞功能，CD8或CD4 T细胞均可提供这种功能。为了确定CD4 T细胞促进恢复所涉及的功能，我们研究了B细胞缺陷型微MT小鼠的感染过程，这些小鼠已通过抗体处理清除了CD8 T细胞。用PR8 [A/PR/8/34(H1N1)]感染后，这种B细胞和CD8 T细胞缺陷型小鼠产生了强烈的CD4 T细胞反应，其大小和细胞因子分泌与完整小鼠相当。然而，与同时含有B细胞和CD4 T细胞的（清除了CD8的）小鼠相比，这些B细胞和CD8 T细胞缺陷型小鼠无法清除感染。这些发现表明，促进T细胞依赖性抗体反应是CD4 T细胞依赖性恢复过程中不可或缺的组成部分。
