Shioiri S, Stuver S O, Okayama A, Murai K, Shima T, Tachibana N, Tsubouchi H, Essex M, Mueller N
Second Department of Internal Medicine, Miyazaki Medical College, Japan.
Int J Cancer. 1998 Jan 5;75(1):15-8. doi: 10.1002/(sici)1097-0215(19980105)75:1<15::aid-ijc3>3.0.co;2-4.
To assess the relationship of anti-Tax antibody to human T-cell lymphotropic virus type-I (HTLV-I) transmission, the sero-prevalence of HTLV-I was analyzed among married couples and among mother/child (both adults) pairs. HTLV-I seroprevalence was significantly higher among wives with anti-Tax+ than those with anti-Tax- HTLV-I carrier husbands (82.4% vs. 59.5%). However, in the group of wives aged 60 years or older, there was no statistical difference in HTLV-I seropositivity based on the husbands' anti-Tax sero-status. In the group whose wives were less than 60 years old, more anti-Tax sero-positive than sero-negative husbands had high DNA levels (57.1% and 20.0%), whereas in the group of husbands whose wives were aged 60 years or older, the number of anti-Tax sero-positive and sero-negative individuals with high DNA levels was similar. HTLV-I sero-prevalence was significantly higher among the adult men with anti-Tax+ carrier mothers than those with anti-Tax- carrier mothers (52.0% vs. 14.3%). For women, HTLV-I sero-prevalence did not differ significantly according to their mothers' anti-Tax sero-status. Our results suggest that the presence of anti-Tax antibody in HTLV-I carriers is an age-dependent risk factor for male-to-female HTLV-I transmission. Furthermore, the effect of the mother's anti-Tax antibody as a risk factor for vertical HTLV-I transmission could be observed in men even after becoming adults.
为评估抗Tax抗体与I型人类嗜T淋巴细胞病毒（HTLV-I）传播之间的关系，我们分析了已婚夫妇以及母婴（均为成年人）对中HTLV-I的血清流行率。抗Tax阳性的HTLV-I携带者丈夫的妻子中，HTLV-I血清流行率显著高于抗Tax阴性的妻子（82.4%对59.5%）。然而，在60岁及以上的妻子组中，基于丈夫的抗Tax血清状态，HTLV-I血清阳性率无统计学差异。在妻子年龄小于60岁的组中，抗Tax血清阳性的丈夫比血清阴性的丈夫有更高的DNA水平（57.1%和20.0%），而在妻子年龄60岁及以上的丈夫组中，抗Tax血清阳性和血清阴性且DNA水平高的个体数量相似。抗Tax阳性的携带者母亲的成年男性中，HTLV-I血清流行率显著高于抗Tax阴性的携带者母亲的成年男性（52.0%对14.3%）。对于女性，HTLV-I血清流行率根据其母亲的抗Tax血清状态无显著差异。我们的结果表明，HTLV-I携带者中抗Tax抗体的存在是男性向女性传播HTLV-I的年龄依赖性风险因素。此外，即使在成年后，男性中也可观察到母亲的抗Tax抗体作为垂直传播HTLV-I风险因素的作用。
