Cheng H W, Jiang T, Mori N, McNeill T H
Division of Neurogerontology, Andrus Gerontology Center, University of Southern California, Los Angeles 90089-0191, USA.
Neuroreport. 1997 Dec 1;8(17):3691-5. doi: 10.1097/00001756-199712010-00007.
Stathmin (p19) is developmentally regulated as a neural-enriched phosphoprotein associated with neurite outgrowth and synaptic formation during cell proliferation and differentiation, and remains highly abundant in adult rat brain. Whether stathmin is involved in injury-induced reactive synaptogenesis in adult rat was examined in this study. Following unilateral cortical lesion, a significant increase in stathmin mRNA expression was found in the cells of contralateral homotypic cortex and in the subventricular zone of the lateral ventricle. This increase coincided in time with the corticostriatal axon sprouting and synaptic remodeling previously found in denervated striatum. Our data suggest that stathmin plays an important role in regulation of reactive synaptogenesis in adult brain.
微管相关蛋白（p19）在发育过程中受到调控，是一种在细胞增殖和分化过程中与神经突生长及突触形成相关的富含神经组织的磷蛋白，在成年大鼠脑中含量依然很高。本研究检测了微管相关蛋白是否参与成年大鼠损伤诱导的反应性突触形成。单侧皮质损伤后，在对侧同型皮质细胞及侧脑室室下区发现微管相关蛋白mRNA表达显著增加。这种增加在时间上与先前在去神经支配的纹状体中发现的皮质纹状体轴突发芽和突触重塑相一致。我们的数据表明，微管相关蛋白在成年大脑反应性突触形成的调控中发挥重要作用。
