聚肌苷酸-聚胞苷酸对经干扰素处理细胞的毒性。超微结构评估。

Toxicity of poly(rI).poly(rC) for interferon-treated cells. An ultrastructural evaluation.

作者信息

Heremans H, Stewart W E, Billiau A, De Somer P

出版信息

J Gen Virol. 1976 Jan;30(1):131-5. doi: 10.1099/0022-1317-30-1-131.

Abstract

The cytotoxic effect of poly(rI).poly(rC) for interferon-treated cells is preceded by discrete ultrastructural alterations in (1) the mitochondria: swelling of the cristae and increased density of their matrix, (2) the nucleus: disorganization of the structure, and (3) the endoplasmic reticulum: slight dilatation with disorganization and depletion of the filament bundles. Our results do not allow us to conclude whether any of these alterations is a primary effect of the treatment. Possibly they are secondary to some, as yet unknown, functional defect, and only reflect incipient cell death.

摘要

聚肌苷酸-聚胞苷酸（poly(rI).poly(rC)）对经干扰素处理的细胞的细胞毒性作用之前，（1）线粒体出现离散的超微结构改变：嵴肿胀，基质密度增加；（2）细胞核结构紊乱；（3）内质网轻微扩张，细丝束紊乱和减少。我们的结果无法让我们得出这些改变是否是治疗的主要作用。它们可能是继发于某种尚未知晓的功能缺陷，仅反映了初期的细胞死亡。