Ramírez E, Villaverde A
Institut de Biologia Fonamental and Departament de Genètica i Microbiologia, Universitat Autònoma de Barcelona, Spain.
Gene. 1997 Nov 20;202(1-2):147-9. doi: 10.1016/s0378-1119(97)00467-8.
The viral spread within isolated host populations has been studied throughout the growth of P22-infected Salmonella cell colonies. By using an integration mutant of this bacteriophage, horizontal and vertical transmission have been analyzed independently. The data obtained show that both strategies are not simultaneous but consecutive during the colony development. Lytic cycles are tightly repressed during the exponential cell growth but stimulated in independent colonies with remarkable synchrony when the cell division rate decreases. The coincidence of the viral outburst and the decay of bacterial replicative fitness is a new example of the extreme viral competence in exploiting the host cells as dissemination vehicles for viral genomes.
在P22感染的沙门氏菌细胞菌落生长过程中，对病毒在隔离宿主群体中的传播进行了研究。通过使用这种噬菌体的整合突变体，分别分析了水平和垂直传播。获得的数据表明，在菌落发育过程中，这两种传播策略并非同时发生，而是相继发生。在指数期细胞生长期间，裂解周期受到严格抑制，但当细胞分裂速率下降时，在独立菌落中会以显著的同步性被激活。病毒爆发与细菌复制适应性下降的同时出现，是病毒在利用宿主细胞作为病毒基因组传播载体方面具有极强能力的一个新例子。
