Holm R, Flørenes V A, Erikstein B, Nesland J M
Department of Pathology, Norwegian Radium Hospital, Oslo, Norway.
Anticancer Res. 1997 Sep-Oct;17(5B):3725-7.
Matrix metalloproteinases are belived to play a central role in the invasion and metastasis of human cancers by mediating the degration of extracellular matrix components. Expression of stromelysin-3 (ST3), a new member of matrix metalloproteinase family, was investigated by in situ hybridization in 32 tissue samples of medullary carcinoma of the breast. Eighty-four per cent of the cases showed ST3 gene expression in stromal cells adjacent to tumor cells. Therefore, expression of ST3 in stromal cells may be expected to play a significant role in the destruction of extracellular matrix and invasion of medullary carcinoma of the breast.
基质金属蛋白酶被认为通过介导细胞外基质成分的降解在人类癌症的侵袭和转移中起核心作用。通过原位杂交技术，对32例乳腺髓样癌组织样本中基质金属蛋白酶家族的新成员基质溶素-3（ST3）的表达情况进行了研究。84%的病例显示肿瘤细胞邻近的基质细胞中有ST3基因表达。因此，可以预期基质细胞中ST3的表达在乳腺髓样癌的细胞外基质破坏和侵袭过程中发挥重要作用。
