Kawaguchi T, Yamamoto S, Kudoh S, Goto K, Wakasa K, Sakurai M
Department of Internal Medicine, National Kinki Central Hospital, Osaka, Japan.
Anticancer Res. 1997 Sep-Oct;17(5B):3743-6.
We investigated the correlation between tumor angiogenesis and prognosis of T1N0M0 lung adenocarcinoma.
Forty two specimens resected from patients with T1NOM0 lung adenocarcinoma were investigated by immunohistochemical staining with a monoclonal antibody to CD31. The relationship between microvessel count, clinicopathologic factors and prognosis was studied.
The microvessel count was significantly higher in cases with vessel invasions than in those without. Univariate analysis showed that microvessel count was related to poorer prognosis. In patients with a high microvessel count (> or = 38), prognosis was significantly poorer than in those with a low count (< 38). Multivariate analysis indicated that the microvessel count and mitosis are prognostic factors in patients with lung cancer, and that the microvessel count is a more important factor than mitosis.
Microvessel count may be a major prognostic factor and a useful tool to predict recurrence in patients with T1N0M0 lung adenocarcinoma.
我们研究了肿瘤血管生成与T1N0M0肺腺癌预后之间的相关性。
采用抗CD31单克隆抗体免疫组化染色法，对42例T1N0M0肺腺癌患者切除的标本进行研究。研究微血管计数、临床病理因素与预后之间的关系。
有血管侵犯的病例微血管计数显著高于无血管侵犯的病例。单因素分析显示微血管计数与较差的预后相关。微血管计数高（≥38）的患者预后明显比计数低（<38）的患者差。多因素分析表明，微血管计数和有丝分裂是肺癌患者的预后因素，且微血管计数比有丝分裂更重要。
微血管计数可能是T1N0M0肺腺癌患者的主要预后因素及预测复发的有用工具。
