Park Seung Ha, Lee Seung Sei
Department of Internal Medicine, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine, Seoul, Korea.
Korean J Intern Med. 2003 Dec;18(4):207-11. doi: 10.3904/kjim.2003.18.4.207.
VEGF is an important factor for angiogenesis. Although many previous studies have reported an increased serum VEGF concentration in various malignant tumors, there are few studies on the relationship between serum VEGF concentration and its prognosis. This study investigated whether serum VEGF concentration is a prognostic indicator for lung cancer.
Using the ELISA kit, we measured the serum VEGF concentrations of 86 patients diagnosed with lung cancer on histologic examination. With a cut off value of 686 pg/mL, the patients were classified as low-concentration (< 686 pg/mL, n=58) or high-concentration (> or = 686 pg/mL, n=28) based on their mean serum VEGF concentration values to compare survival rates, and serum VEGF concentrations for different histologic types and stages.
There was no significant difference in serum VEGF concentration based on stage and histologic type between the two groups. Moreover, there was no significant difference in survival rate between the high-concentration and low-concentration groups (p=0.86).
This study demonstrates that serum VEGF concentration is not associated with the prognosis of lung cancer.
血管内皮生长因子（VEGF）是血管生成的一个重要因素。尽管此前许多研究报道了各种恶性肿瘤患者血清VEGF浓度升高，但关于血清VEGF浓度与其预后之间关系的研究却很少。本研究调查了血清VEGF浓度是否为肺癌的预后指标。
我们使用酶联免疫吸附测定（ELISA）试剂盒，对86例经组织学检查确诊为肺癌的患者的血清VEGF浓度进行了测量。以686 pg/mL为临界值，根据患者血清VEGF浓度平均值将其分为低浓度组（<686 pg/mL，n = 58）或高浓度组（≥686 pg/mL，n = 28），以比较生存率以及不同组织学类型和分期的血清VEGF浓度。
两组之间基于分期和组织学类型的血清VEGF浓度无显著差异。此外，高浓度组和低浓度组的生存率也无显著差异（p = 0.86）。
本研究表明血清VEGF浓度与肺癌预后无关。
