Akimoto T, Takahashi I, Takahashi M, Yamakawa M, Hayakawa K, Mitsuhashi N, Niibe H
Department of Radiology and Radiation Oncology, Gunma University School of Medicine, Japan.
Anticancer Res. 1997 Sep-Oct;17(5B):3781-5.
To evaluate the treatment-related late sequelae including gonadal function and second malignancy 94 patients with stage I and II testicular seminoma treated with postorchiectomy radiation therapy were analyzed retrospectively. The 10-year cause specific, disease free and actuarial survival rates were 100, 98.5 and 96.1% for stage II and 91.7, 83.3 and 91.7% for stage II, respectively. The most common late sequelae of gastrointestinal tract was peptic ulcer, developing in 16% of all patients with a median interval of 12 months, but severity was mild except one who needed subtotal gastrectomy. Second malignancies developed in 9 patients (9.5%) with a median interval of 13 years, but calculated O/E ratio excluding 2 patients with secondary germ cell tumor of contralateral testis was 2.3 and did not reach a significant level statistically. Concerning gonadal function assessed from the number of the children, 79% of the patients who wanted to have children after the treatment were successful in fathering children. No fatal complications were observed.
为评估包括性腺功能和第二原发恶性肿瘤在内的与治疗相关的晚期后遗症，我们对94例接受睾丸切除术后放射治疗的Ⅰ期和Ⅱ期睾丸精原细胞瘤患者进行了回顾性分析。Ⅱ期患者的10年病因特异性生存率、无病生存率和精算生存率分别为100%、98.5%和96.1%，Ⅰ期患者分别为91.7%、83.3%和91.7%。胃肠道最常见的晚期后遗症是消化性溃疡，在所有患者中的发生率为16%，中位间隔时间为12个月，但除1例需要行胃大部切除术的患者外，严重程度均较轻。9例患者（9.5%）发生了第二原发恶性肿瘤，中位间隔时间为13年，但排除2例对侧睾丸继发性生殖细胞肿瘤患者后计算的观察/预期比值为2.3，未达到统计学显著水平。从生育子女数量评估性腺功能，79%希望在治疗后生育的患者成功育有子女。未观察到致命并发症。
