Fink J B
Division of Pulmonary and Critical Care Medicine, Loyola University of Chicago Stritch School of Medicine, and Hines Veterans Hospital, Illinois, USA.
Respir Care. 2000 Jun;45(6):623-35.
Since 1956, the pMDI has become the most commonly prescribed and used aerosol device in the world. While concerns about global warming have led to a worldwide ban of CFCs, new HFA-propelled pMDIs are in development, requiring an evolutionary transition in the technology. The phase-out of CFC-propelled pMDIs has stimulated the development of more efficient DPIs, but issues such as cost of device production, inspiratory flow requirement, and the effects of ambient humidity on drug delivery may limit DPI acceptance, and industry projections suggest that the DPI will not completely replace the pMDI. Holding chambers may perform differently with HFA-propelled pMDIs, but HFA-propelled pMDIs generally appear to cause less oropharyngeal deposition and to improve lung delivery while continuing to provide protection from poor hand-breath coordination. The initial offerings of the emerging HFA-propelled pMDI technology appear to be resulting in an improved pMDI.
自1956年以来，压力定量吸入器（pMDI）已成为全球处方量和使用量最多的雾化装置。由于对全球变暖的担忧导致全球禁用氯氟烃（CFC），新型氢氟烷烃（HFA）推进的pMDI正在研发中，这需要技术上的逐步转变。淘汰以CFC推进的pMDI刺激了更高效干粉吸入器（DPI）的发展，但诸如装置生产成本、吸气流量要求以及环境湿度对药物递送的影响等问题可能会限制DPI的接受度，并且行业预测表明DPI不会完全取代pMDI。储物罐与HFA推进的pMDI配合使用时可能表现不同，但HFA推进的pMDI通常似乎导致较少的口咽沉积并改善肺部递送，同时继续提供防止手与呼吸协调不佳的保护作用。新兴的HFA推进的pMDI技术的初步产品似乎正在带来改良的pMDI。
