Aramayona J J, Bregante M A, Solans C, Rueda S, Fraile L J, Garcia M A
Department of Pharmacology and Physiology, Veterinary Faculty, University of Zaragoza, Spain.
Vet Res. 1997 Nov-Dec;28(6):581-8.
This paper describes the pharmacokinetics of fosfomycin following a single i.v. bolus dose (10 mg/kg of body weight) in broiler chickens. Serial blood samples were collected up to 5 h post-administration. Fosfomycin serum concentrations were determined by a microbiological method, using Proteus mirabilis as the test microorganism. The serum concentration versus time curves after i.v. administration followed a biexponential decline. The main pharmacokinetic variables were t1/2 lambda l = 23 min, t1/2 lambda n = 112 min, VDarea = 575 +/- 190 mL/kg and CLb = 3.12 +/- 0.44 mL.min-1.kg-1. Tissue levels of fosfomycin in kidney, liver, lung, muscle, heart, fat, gizzard and serum were also determined after oral chronic administration of the drug in drinking water (150 micrograms/mL). During the oral chronic administration period, high FOS concentrations in serum were maintained (mean 6.1 +/- 1.1 micrograms/mL), but a significant decline over time could be observed (P < 0.05). Fosfomycin was detected in all tissues except muscle, with mean concentrations ranging from 0.63 microgram/g in fat to 13.48 micrograms/g in kidney. Twenty-four hours after the treatment was finished, fosfomycin levels were below the assay detection limit in all tissues tested.
本文描述了在肉鸡中单次静脉推注剂量（10毫克/千克体重）磷霉素后的药代动力学。给药后长达5小时采集系列血样。磷霉素血清浓度通过微生物学方法测定，使用奇异变形杆菌作为测试微生物。静脉给药后的血清浓度-时间曲线呈双指数下降。主要药代动力学变量为t1/2λl = 23分钟，t1/2λn = 112分钟，VDarea = 575±190毫升/千克，CLb = 3.12±0.44毫升·分钟-1·千克-1。在饮用水中口服慢性给药（150微克/毫升）该药物后，还测定了肾脏、肝脏、肺、肌肉、心脏、脂肪、砂囊和血清中的磷霉素组织水平。在口服慢性给药期间，血清中维持了高磷霉素浓度（平均6.1±1.1微克/毫升），但随时间可观察到显著下降（P<0.05）。除肌肉外，在所有组织中均检测到磷霉素，平均浓度范围从脂肪中的0.63微克/克到肾脏中的13.48微克/克。治疗结束24小时后，在所有测试组织中磷霉素水平均低于检测限。
