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艾滋病毒和获得性免疫缺陷综合征(AIDS)患者中抗弓形虫IgG和IgM抗体的患病率。

Prevalence of IgG and IgM anti-Toxoplasma antibodies in patients with HIV and acquired immunodeficiency syndrome (AIDS).

作者信息

Galván Ramírez M L, Valdez Alvarado V, Vargas Gutierrez G, Jiménez González O, García Cosio C, Vielma Sandoval M

机构信息

Centro de Investigación en Enfermedades Tropicales, Universidad de Guadalajara, Mexico.

出版信息

Rev Soc Bras Med Trop. 1997 Nov-Dec;30(6):465-7. doi: 10.1590/s0037-86821997000600004.

Abstract

With the emergence of the human immunodeficiency virus (HIV), in patients with acquired immunodeficiency syndrome (AIDS), Toxoplasma gondii has arisen as an important opportunist pathogenic agent, especially in the central nervous system, being the most common cause of intracerebral lesions. The incidence of Toxoplasma gondii in HIV-infected patients depends principally on the existence of latent Toxoplasma parasitosis in the population affected. Through the enzyme-linked immunosorbent assay (ELISA), IgG and IgM anti-Toxoplasma antibodies were found in 92 patients of which 46 (50.0%) were IgG seropositive, and only one case (1.0%) had IgM antibodies. Of the 92 patients: 53 were HIV seropositives and 39 had AIDS. The detection and monitoring of anti-Toxoplasma antibodies in HIV patients is essential, since in this group there is a high percentage risk of developing cerebral toxoplasmosis, which is the second cause of death in this type of patients.

摘要

随着人类免疫缺陷病毒(HIV)的出现,在获得性免疫缺陷综合征(AIDS)患者中,弓形虫已成为一种重要的机会致病性病原体,尤其是在中枢神经系统,是脑内病变的最常见原因。HIV感染患者中弓形虫的发病率主要取决于受影响人群中潜伏性弓形虫寄生的存在情况。通过酶联免疫吸附测定(ELISA),在92例患者中发现了IgG和IgM抗弓形虫抗体,其中46例(50.0%)IgG血清学阳性,只有1例(1.0%)有IgM抗体。在这92例患者中:53例为HIV血清阳性,39例患有AIDS。对HIV患者抗弓形虫抗体的检测和监测至关重要,因为在这组患者中发生脑弓形虫病的风险百分比很高,脑弓形虫病是这类患者的第二大死因。

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