Miletich D J, Ivankovich A D, Albrecht R F, Reimann C R, Rosenberg R, McKissic E D
Anesth Analg. 1976 Jan-Feb;55(1):100-9. doi: 10.1213/00000539-197601000-00024.
The effects of halothane and enflurane anesthesia under conditions of normo-, hyper-, and hypocarbia on the autoregulation of cerebral blood flow (CBF) in the goat were evaluated. The goat was selected because of its unique arterial blood supply to the head and the development of a method by which CBF may be continuously measured. The study revealed that 1 MAC of halothane or enflurane anesthesia at normocarbia abolished cerebral autoregulation, CBF increasing or decreasing with increasing or decreasing peripheral blood pressure. Reduction of anesthesia to 0.5 MAC partially restored cerebral autoregulatory capability. The effect of 1 MAC and 0.5 MAC anesthesia on cerebral autoregulation of blood flow was potentiated by hypercarbia and antagonized by hypocarbia, indicating that the vascular response to blood CO2 fluctuations remained intact.
评估了氟烷和恩氟烷麻醉在正常碳酸血症、高碳酸血症和低碳酸血症条件下对山羊脑血流（CBF）自动调节的影响。选择山羊是因为其头部独特的动脉血液供应以及已开发出一种可连续测量CBF的方法。研究表明，在正常碳酸血症时，1个最低肺泡有效浓度（MAC）的氟烷或恩氟烷麻醉会消除脑自动调节功能，CBF随外周血压升高或降低而增加或减少。将麻醉浓度降至0.5 MAC可部分恢复脑自动调节能力。高碳酸血症会增强1 MAC和0.5 MAC麻醉对脑血流自动调节的影响，而低碳酸血症则会起到拮抗作用，这表明血管对血液二氧化碳波动的反应仍然完好。
