Cavalla P, Schiffer D
Department of Neuroscience, University of Turin, Italy.
Anticancer Res. 1997 Nov-Dec;17(6B):4135-43.
Cell proliferation is characteristic, though non specific, of tumors. The cell cycle is regarded as a clock with ordered activation of protein complexes triggering initiation and advancement through checkpoints. The cell cycle and its control mechanisms are briefly described herein focusing on neuroepithelial tumors. The assessment of cell proliferation in brain tumors is a very important tool in diagnosis and especially in prognosis. It can be performed by different methods: counting mitoses, calculating the labeling index (Ll) of [3H] Thymidine, BrdU, Ki-67, MIB.1, PCNA, cytometry and AgNORs. Each method has its advantages and disadvantages. The main obstacles to the usefulness of different Lls in establishing prognosis in individual cases are sampling error, heterogeneity of the proliferation potential of brains tumors and the wide overlapping of Ll ranges between classic and anaplatic variants. The principal findings are critically described and commented upon.
细胞增殖是肿瘤的一个特征，尽管不具有特异性。细胞周期被视为一个时钟，蛋白质复合物按顺序激活，触发通过检查点的启动和推进。本文简要描述细胞周期及其控制机制，重点关注神经上皮肿瘤。评估脑肿瘤中的细胞增殖是诊断尤其是预后评估的一项非常重要的工具。它可以通过不同方法进行：计数有丝分裂、计算[3H]胸腺嘧啶核苷、BrdU、Ki-67、MIB.1、PCNA的标记指数（LI）、细胞计数法和核仁组成区嗜银蛋白计数法。每种方法都有其优缺点。不同LI在个别病例中用于判断预后的主要障碍是取样误差、脑肿瘤增殖潜能的异质性以及典型和间变性变体之间LI范围的广泛重叠。对主要研究结果进行了批判性描述和评论。
