Pignoni F, Hu B, Zavitz K H, Xiao J, Garrity P A, Zipursky S L
Department of Biological Chemistry, The School of Medicine, University of California, Los Angeles 90095, USA.
Cell. 1997 Dec 26;91(7):881-91. doi: 10.1016/s0092-8674(00)80480-8.
Sine oculis (so) and eyes absent (eya) are required for Drosophila eye development and are founding members of the mammalian Six and Eya gene families. These genes have been proposed to act with eyeless (Pax6) to regulate eye development in vertebrates and invertebrates. so encodes a highly diverged homeobox transcription factor and eya encodes a novel nuclear protein. We demonstrate that So and Eya (1) regulate common steps in eye development including cell proliferation, patterning, and neuronal development; (2) synergize in inducing ectopic eyes; and (3) interact in yeast and in vitro through evolutionarily conserved domains. We propose that an So/Eya complex regulates multiple steps in eye development and functions within the context of a network of genes to specify eye tissue identity.
无眼基因（so）和眼缺失基因（eya）是果蝇眼睛发育所必需的，并且是哺乳动物Six和Eya基因家族的创始成员。这些基因被认为与无眼基因（Pax6）共同作用，以调节脊椎动物和无脊椎动物的眼睛发育。so编码一种高度分化的同源异型盒转录因子，eya编码一种新型核蛋白。我们证明，So和Eya（1）调节眼睛发育中的共同步骤，包括细胞增殖、模式形成和神经元发育；（2）协同诱导异位眼；（3）在酵母和体外通过进化保守结构域相互作用。我们提出，So/Eya复合物调节眼睛发育中的多个步骤，并在基因网络的背景下起作用，以确定眼组织身份。
