Suzuki A, Katoh T, Ikeda K
Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Japan.
Anesth Analg. 1998 Jan;86(1):179-83. doi: 10.1097/00000539-199801000-00035.
We evaluated the effects of i.v. adenosine triphosphate (ATP) on sevoflurane minimum alveolar anesthetic concentration (MAC) and MAC-Awake. The study group included healthy patients 20-60 yr of age. The study groups for MAC-Awake determination included 49 patients who were scheduled for elective surgery. The study groups for MAC determination included 53 patients scheduled for elective surgery involving a skin incision. These patients were randomly assigned to two groups, an ATP group and a control group. The ATP group received 100 micrograms.kg-1.min-1 ATP i.v., and the control group received no medication. The ATP group and the control group were compared with regard to MAC-Awake (anesthetic concentration achieving 50% probability of eye opening in response to a verbal command) and MAC (anesthetic concentration achieving 50% probability of no movement in response to skin incision). The MAC-Awake was 0.7% +/- 0.1% in the control group (mean +/- SD) and 0.7% +/- 0.1% in the ATP group. MAC was 1.9% +/- 0.1% in the control group and 2.1% +/- 0.2% in the ATP group. The differences in MAC and MAC-Awake between the two groups were not statistically significant. We conclude that ATP infusion (100 micrograms.kg-1.min-1) has no effect on sevoflurane MAC and MAC-Awake.
We found that an i.v. adenosine triphosphate infusion (100 micrograms.kg-1.min-1) has no effect on sevoflurane minimum alveolar anesthetic concentration (anesthetic concentration achieving 50% probability of no movement in response to skin incision) and minimum alveolar anesthetic concentration-Awake (anesthetic concentration achieving 50% probability of eye opening in response to a verbal command) in humans.
我们评估了静脉注射三磷酸腺苷（ATP）对七氟醚最低肺泡有效浓度（MAC）和清醒MAC的影响。研究组包括年龄在20至60岁的健康患者。用于确定清醒MAC的研究组包括49例计划进行择期手术的患者。用于确定MAC的研究组包括53例计划进行涉及皮肤切口的择期手术的患者。这些患者被随机分为两组，ATP组和对照组。ATP组静脉注射100微克·千克-1·分钟-1的ATP，对照组不接受任何药物治疗。比较了ATP组和对照组在清醒MAC（对言语指令有50%睁眼概率时的麻醉浓度）和MAC（对皮肤切口有50%无运动概率时的麻醉浓度）方面的差异。对照组的清醒MAC为0.7%±0.1%（平均值±标准差），ATP组为0.7%±0.1%。对照组的MAC为1.9%±0.1%，ATP组为2.1%±0,2%。两组之间MAC和清醒MAC的差异无统计学意义。我们得出结论，输注ATP（100微克·千克-1·分钟-1）对七氟醚MAC和清醒MAC没有影响。
我们发现，静脉输注三磷酸腺苷（100微克·千克-1·分钟-1）对人体七氟醚最低肺泡有效浓度（对皮肤切口有50%无运动概率时的麻醉浓度）和最低肺泡有效浓度-清醒（对言语指令有50%睁眼概率时的麻醉浓度）没有影响。
