Senyuva C, Yücel A, Erdamar S, Cetinkale O, Seradjmir M, Ozdemir C
Department of Plastic and Reconstructive Surgery, Cerrahpaşa Medical Faculty, Istanbul University, Turkey.
Burns. 1997 Sep;23(6):484-9. doi: 10.1016/s0305-4179(97)00043-0.
The behavior, under burn scars, of three different alloplastic materials, silicone, Medpor and Proplast, was compared in an animal model. A standard burn wound was created in rats, and 3 months later silicone, medpor and proplast alloplasts were placed under the burn scar. The rats were followed for another 3 months and ulceration and/or alloplast exposure rates were evaluated. At the end of this period specimens were examined histologically for the thickness of the fibrous capsule around the implant, thickness of the overlying tissue, tissue ingrowth and vascularization of the implants. Ulceration and exposure occurred in 2 of the 12 Medpor, 2 of the 12 Proplast and none of the 12 silicone implants. Fibrous capsule was significantly thicker around the silicone implants. Tissue ingrowth and vascularization were most prominent in Medpor implants while thickness of the overlying tissue was maximum in Proplast implants. These findings suggest that complications with silicone implants may be less than with other porous implants when used under burn scarred tissue.
在动物模型中比较了三种不同的异体植入材料（硅酮、Medpor和Proplast）在烧伤瘢痕下的表现。在大鼠身上制造标准烧伤创面，3个月后将硅酮、Medpor和Proplast异体植入物置于烧伤瘢痕下。对大鼠再随访3个月，评估溃疡和/或植入物暴露率。在此期间结束时，对标本进行组织学检查，以确定植入物周围纤维囊的厚度、覆盖组织的厚度、组织向内生长情况以及植入物的血管化情况。12个Medpor植入物中有2个发生溃疡和暴露，12个Proplast植入物中有2个发生溃疡和暴露，12个硅酮植入物均未发生溃疡和暴露。硅酮植入物周围的纤维囊明显更厚。Medpor植入物中的组织向内生长和血管化最为显著，而Proplast植入物上覆盖组织的厚度最大。这些发现表明，当在烧伤瘢痕组织下使用时，硅酮植入物的并发症可能比其他多孔植入物少。
