Larson B A, Sinha Y N, Vanderlaan W P
Endocrinology. 1976 Jan;98(1):139-45. doi: 10.1210/endo-98-1-139.
Mice with the recessively inherited obese-hyperglycemic syndrome (ob/ob) and their nonobese litter mates were studied over a 26-week period. The body weights and serum glucose levels of ob/ob mice began to rise markedly at 5-6 weeks of age and remained elevated throughout the period of study. Obese mice were significantly heavier (P less than .001) and had higher serum glucose levels (P less than .001) than lean mice, but obese mice had variably lower serum growth hormone (GH) and prolactin (PRL) levels (P less than .001) than lean litter mate controls after 4-5 weeks of life. A 24 h rhythm study performed on 15-week-old mice revealed a relatively unaltered but attenuated pattern of GH and PRL secretion in ob/ob mice. During and after the development of the obese-hyperglycemic syndrome, the low levels of these two hormones probably indicates an altered hypothalamic regulation of pituitary function.
对患有隐性遗传的肥胖 - 高血糖综合征（ob/ob）的小鼠及其非肥胖同窝仔鼠进行了为期26周的研究。ob/ob小鼠的体重和血清葡萄糖水平在5 - 6周龄时开始显著上升，并在整个研究期间持续升高。肥胖小鼠比瘦小鼠明显更重（P < 0.001）且血清葡萄糖水平更高（P < 0.001），但在出生4 - 5周后，肥胖小鼠的血清生长激素（GH）和催乳素（PRL）水平比瘦同窝对照小鼠有不同程度的降低（P < 0.001）。对15周龄小鼠进行的24小时节律研究显示，ob/ob小鼠的GH和PRL分泌模式相对未改变但有所减弱。在肥胖 - 高血糖综合征发生期间及之后，这两种激素的低水平可能表明下丘脑对垂体功能的调节发生了改变。
