Jaber L, Merlob P, Gabriel R, Shohat M
Department of Pediatrics, Tulene Medical Center, Tulene University, New Orleans, USA.
J Med Genet. 1997 Dec;34(12):1000-2. doi: 10.1136/jmg.34.12.1000.
Intrafamilial marriage is favoured by the Arab community in Israel, almost all of whom live in villages populated by a few (< 20) founding families. A previous study in Taibe, a large Arab village located 30 km from Tel Aviv, showed a significantly high malformation rate among infants of consanguineous parents. The present study examines the reproductive consequences of parental consanguinity in 610 families from the same village, selected retrospectively through infants routinely seen in the local well baby clinic. All mothers were interviewed with regard to previous pregnancy outcomes, including abortions, stillbirths, and neonatal or infant deaths, as well as the degree of consanguinity. In addition, we analysed the anthropometric measurements of the probands. The incidence of infant deaths was significantly higher in the inbred group (p < 0.001). No significant increase in fetal loss between the inbred and outbred groups was observed. There were no differences in anthropometric features, except for a lower birth weight in the consanguineous group (p < 0.035). This study, combined with our previous studies of the same population, indicates a prominent public health problem associated with consanguineous marriage in the Arab community and a need for specific genetic counselling.
以色列的阿拉伯社区倾向于近亲结婚，他们几乎都生活在由少数（<20个）创始家族聚居的村庄。此前在距离特拉维夫30公里的一个大型阿拉伯村庄泰贝进行的一项研究表明，近亲父母的婴儿中畸形率显著偏高。本研究调查了来自同一村庄的610个家庭中父母近亲结婚对生育的影响，这些家庭是通过当地健康婴儿诊所的常规就诊婴儿进行回顾性选取的。所有母亲都接受了关于既往妊娠结局的访谈，包括流产、死产以及新生儿或婴儿死亡情况，还有近亲结婚的程度。此外，我们分析了先证者的人体测量数据。近亲结婚组的婴儿死亡率显著更高（p<0.001）。近亲结婚组和非近亲结婚组之间的胎儿丢失率没有显著增加。人体测量特征方面没有差异，只是近亲结婚组的出生体重较低（p<0.035）。这项研究与我们之前对同一人群的研究相结合，表明阿拉伯社区中近亲结婚存在一个突出的公共卫生问题，并且需要进行特定的遗传咨询。
