沙特人群中的近亲结婚与糖尿病：一项病例对照研究。
Consanguinity and Diabetes in Saudi Population: A Case-Control Study.
作者信息
Alzahrani Saad H, Alzahrani Nawaf M, Al Jabir Fahad M, Alsharef Mohammed K, Zaheer Shawana, Hussein Salma H, Alguwaihes Abdullah M, Jammah Anwar A
机构信息
Obesity and Endocrine Metabolism Center, King Fahad Medical City, Riyadh, SAU.
College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, SAU.
出版信息
Cureus. 2021 Dec 30;13(12):e20836. doi: 10.7759/cureus.20836. eCollection 2021 Dec.
BACKGROUND AND AIM
Diabetes mellitus (DM) of both types is a genetically determined disorder and is prevalent in the Saudi population. Furthermore, the rate of consanguineous marriages is also high among Saudis. Therefore, we aimed to determine the prevalence of consanguinity among people with DM and investigate the effect of consanguinity on the occurrence of diabetes at different levels.
METHODS
A descriptive cross-sectional study was carried out at the Obesity, Metabolism and Endocrine Center of King Fahad Medical City in Riyadh, Saudi Arabia in January 2021. Information on patients' demographics (age, gender), family history of DM, and presence of consanguinity, and degree of consanguineous marriage were collected.
RESULTS
We included 324 people with DM, 143 (44.1%) with type 1 diabetes (T1DM), and 181 (55.9%) with type 2 diabetes (T2DM). We included 201 people without DM for T1DM control and 300 people for T2DM control. The mean age was 26.6 ± 11.1 years for the T1DM group and 57.8 ± 11.6 years for the T2DM group. Consanguinity was noted among 73 (51.4%) T1DM patients, but T1DM was not significantly related to consanguinity. T2DM was significantly correlated with consanguinity (r=0.132, p=0.004) particularly among patients with a degree of consanguinity as first-cousins for both paternal and maternal sides (odds ratio [OR]=1.151 and 1.476). Gender and positive family history for DM and consanguineous marriage between cousins were significant factors for T2DM. After controlling for gender and a positive family history of DM, consanguineous marriage between cousins from both the paternal and maternal sides remained significant.
CONCLUSION
T2DM occurrence increases in presence of consanguinity in the Saudi population. This relationship might contribute to the higher risk of DM prevalence. Further studies are needed to elucidate this relationship deeply. It's unclear whether lowering consanguineous marriages would decrease the prevalence of diabetes or not. However, a clear message about this correlation has to be delivered to the public.
背景与目的
两种类型的糖尿病（DM）都是由基因决定的疾病，在沙特人群中普遍存在。此外，沙特人的近亲结婚率也很高。因此，我们旨在确定糖尿病患者中近亲结婚的比例，并研究近亲结婚在不同程度上对糖尿病发生的影响。
方法
2021年1月，在沙特阿拉伯利雅得法赫德国王医疗城的肥胖、代谢与内分泌中心进行了一项描述性横断面研究。收集了患者的人口统计学信息（年龄、性别）、糖尿病家族史、近亲结婚情况以及近亲结婚的程度。
结果
我们纳入了324名糖尿病患者，其中143名（44.1%）为1型糖尿病（T1DM）患者，181名（55.9%）为2型糖尿病（T2DM）患者。我们纳入了201名非糖尿病患者作为T1DM对照组，300名作为T2DM对照组。T1DM组的平均年龄为26.6±11.1岁，T2DM组为57.8±11.6岁。73名（51.4%）T1DM患者存在近亲结婚情况，但T1DM与近亲结婚无显著相关性。T2DM与近亲结婚显著相关（r=0.132，p=0.004），尤其是在父母双方均为一级表亲的近亲结婚患者中（优势比[OR]=1.151和1.476）。性别、糖尿病家族史阳性以及表亲之间的近亲结婚是T2DM的重要因素。在控制了性别和糖尿病家族史阳性因素后，父母双方表亲之间的近亲结婚仍然具有显著性。
结论
在沙特人群中，近亲结婚会增加T2DM的发生风险。这种关系可能导致糖尿病患病率升高。需要进一步研究以深入阐明这种关系。目前尚不清楚降低近亲结婚率是否会降低糖尿病患病率。然而，必须向公众传达有关这种相关性的明确信息。
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