Parrott R F, Vellucci S V
MAFF Welfare and Behaviour Laboratory, Department of Neurobiology, Babraham Institute, Cambridge.
Res Vet Sci. 1997 Sep-Oct;63(2):129-31. doi: 10.1016/s0034-5288(97)90005-9.
This study investigated the effects of testosterone on the febrile response of castrated rams to immunological challenge. Core temperature was recorded by radiotelemetry in wethers (n = 6) injected with lipopolysaccharide endotoxin or saline before and after androgen treatment. The number of cells expressing vasopressin mRNA in the brain region implicated in the anti-pyretic response, the bed nucleus of the stria terminalis, was determined by in situ hybridisation histochemistry. Endotoxin, but not androgen, increased vasopressin message (P < 0.05), and androgen also did not alter basal or febrile temperatures. Hence, these preliminary findings question whether the androgen-dependent anti-pyretic mechanism described in the male rat is of physiological significance in the ram.
本研究调查了睾酮对去势公羊免疫应激时发热反应的影响。在雄激素处理前后，通过无线电遥测技术记录了注射脂多糖内毒素或生理盐水的阉羊（n = 6）的核心体温。通过原位杂交组织化学法确定了在与解热反应相关的脑区终纹床核中表达加压素mRNA的细胞数量。内毒素而非雄激素增加了加压素信息（P < 0.05），雄激素也未改变基础体温或发热体温。因此，这些初步研究结果对雄性大鼠中描述的雄激素依赖性解热机制在公羊中是否具有生理意义提出了质疑。
