Wang Z
Department of Psychology, University of Massachusetts, Amherst 01003.
Brain Res Dev Brain Res. 1994 May 13;79(1):147-50. doi: 10.1016/0165-3806(94)90060-4.
To study whether testicular secretions in development have a permanent influence on vasopressin (AVP) messenger RNA expression in the bed nucleus of the stria terminalis (BST) and medial amygdaloid nucleus (MA), male rats that were castrated neonatally or in adulthood were compared after both were similarly treated with testosterone. Males castrated neonatally had fewer cells that were labeled for AVP mRNA and a less density of grains per labeled cell in the BST and MA than males castrated in adulthood. These data indicate that testicular secretions in early development have an organizational effect on AVP mRNA expression in the BST and MA, and this effect was accomplished not only by determining the number of cells that produce AVP, but also by influencing the ability of each individual cell to produce AVP.
为研究发育过程中的睾丸分泌物是否对终纹床核（BST）和杏仁内侧核（MA）中血管加压素（AVP）信使核糖核酸（mRNA）的表达产生永久性影响，对新生期或成年期阉割的雄性大鼠在给予相同睾酮处理后进行了比较。与成年期阉割的雄性大鼠相比，新生期阉割的雄性大鼠在BST和MA中，标记为AVP mRNA的细胞较少，且每个标记细胞的颗粒密度较低。这些数据表明，早期发育中的睾丸分泌物对BST和MA中AVP mRNA的表达具有组织学效应，且这种效应不仅通过决定产生AVP的细胞数量来实现，还通过影响每个细胞产生AVP的能力来实现。
