Bringmann G, Günther C, Busemann S, Schäffer M, Olowokudejo J D, Alo B I
Institut für Organische Chemie der Universität, Würzburg, Germany.
Phytochemistry. 1998 Jan;47(1):37-43. doi: 10.1016/s0031-9422(97)00511-6.
The isolation of three naphthylisoquinoline alkaloids from the leaves of Ancistrocladus guineënsis is described. Their complete structures were established by spectroscopic, chiroptical and degradative methods. Thus, two hitherto unknown 5,8'-coupled naphthylisoquinoline, named ancistroguineines A and B, were isolated, constituting the first example of a pair of 3-epimeric naphthylisoquinoline alkaloids. Moreover, ancistrotectorine, a 7,3'-coupled alkaloid previously known only from the South-East Asian species Ancistrocladus tectorius, was isolated. Its absolute stereostructure was confirmed by oxidative degradation and by comparison of experimental and calculated CD spectra.
描述了从几内亚钩枝藤叶片中分离出三种萘基异喹啉生物碱。通过光谱、旋光和降解方法确定了它们的完整结构。因此，分离出了两种迄今未知的5,8'-偶联萘基异喹啉，命名为钩枝藤碱A和B，它们构成了一对3-差向异构萘基异喹啉生物碱的首个实例。此外，还分离出了钩枝藤保护碱，一种此前仅在东南亚物种长梗钩枝藤中发现的7,3'-偶联生物碱。通过氧化降解以及实验和计算的圆二色光谱比较，确定了其绝对立体结构。
