Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China; School of Life Science & Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Fitoterapia. 2013 Dec;91:305-312. doi: 10.1016/j.fitote.2013.09.010. Epub 2013 Sep 25.
Two new 7,6'-coupled naphthylisoquinolines, namely ancistrotectorines A (1) and B (2), two new 5,3'-coupled naphthylisoquinolines, namely ancistrotectorines C (3) and D (4), and one new 7,8-coupled naphthylisoquinoline, namely ancistrotectorine E (5), together with 9 known naphthylisoquinoline alkaloids, hamatine (6), ancistrobertsonine B (7), ancistrocladinine (8), hamatinine (9), ancistrotanzanine A (10), ancistrotanzanine B (11), ancistrotectoriline B (12), 7-epi-ancistrobrevine D (13), and ancistrotectorine (14), were isolated from the 70% EtOH extract of Ancistrocladus tectorius. Their structures were elucidated based on the extensive analysis of spectroscopic data (1D, 2D NMR and MS). Compound 5 exhibited inhibitory activities against HL-60, K562 and U937 cell lines with IC50 values of 1.70, 4.18 and 2.56 μM respectively.
从钩藤（Ancistrocladus tectorius）的 70%乙醇提取物中分离得到了 10 个萘基异喹啉生物碱，包括 2 个新的 7,6'-偶联萘基异喹啉Ancistrotectorines A (1) 和 B (2)、2 个新的 5,3'-偶联萘基异喹啉Ancistrotectorines C (3) 和 D (4)、1 个新的 7,8-偶联萘基异喹啉 Ancistrotectorine E (5)，以及 9 个已知的萘基异喹啉生物碱，分别为：hamatine (6)、ancistrobertsonine B (7)、ancistrocladinine (8)、hamatinine (9)、ancistrotanzanine A (10)、ancistrotanzanine B (11)、ancistrotectoriline B (12)、7-epi-ancistrobrevine D (13)和 ancistrotectorine (14)。这些化合物的结构是通过广泛的光谱数据分析（1D、2D NMR 和 MS）确定的。化合物 5 对 HL-60、K562 和 U937 细胞系表现出抑制活性，IC50 值分别为 1.70、4.18 和 2.56 μM。
