Miller L J, Wiles-Pfeifler R
Department of Pharmacy, Washington Regional Medical Center, Fayetteville, Ark., USA.
Am J Crit Care. 1998 Jan;7(1):73-6.
To report a case in which propofol was used successfully in an intubated patient on a prolonged basis and to review the literature that discusses long-term infusions (> 7 days) of propofol.
Information was retrieved from a MEDLINE search of the English-language literature. Reports of clinical trials and case reports that compared the safety and efficacy of long-term propofol and midazolam were included in this review. Information about the study design and the efficacy and adverse effects of the drugs was collected, and the data were synthesized.
Clinical reports indicate that a long-term infusion of propofol is comparable in safety and efficacy to a long-term infusion of midazolam. The distinct adverse-effect profile of long-term use of propofol, including hypertriglyceridemia, was evaluated and reported as significant.
The limited data available suggest that long-term infusion of propofol is a practical alternative to use of standard agents for sedation of intubated patients. Adverse effects such as cardiovascular depression, respiratory depression, and hypertriglyceridemia may limit the routine use of propofol.
报告一例成功长期使用丙泊酚进行气管插管患者镇静的病例，并回顾讨论丙泊酚长期输注（>7天）的文献。
通过检索MEDLINE英文文献获取信息。本综述纳入了比较丙泊酚和咪达唑仑长期使用安全性和有效性的临床试验报告及病例报告。收集了有关研究设计以及药物有效性和不良反应的信息，并对数据进行了综合分析。
临床报告表明，丙泊酚长期输注在安全性和有效性方面与咪达唑仑长期输注相当。对长期使用丙泊酚的独特不良反应谱，包括高甘油三酯血症进行了评估，并报告为显著。
现有有限数据表明，长期输注丙泊酚是气管插管患者镇静时使用标准药物的一种实用替代方法。心血管抑制、呼吸抑制和高甘油三酯血症等不良反应可能会限制丙泊酚的常规使用。
