Jaffe F A
Forensic Pathology Unit, Office of the Chief Coroner, Toronto, Ontario, Canada.
Am J Forensic Med Pathol. 1997 Dec;18(4):406-10. doi: 10.1097/00000433-199712000-00017.
The effects of carbon monoxide, one of the most commonly encountered toxic agents in forensic practice, have been known for a long time, but the nature of its bonding to the heme prosthetic group of hemoproteins has only recently been elucidated. In addition to reducing the oxygen capacity of the blood and the consequent systemic hypoxia, carbon monoxide interferes with the dissociation of oxyhemoglobin and the removal of carbon dioxide. Carbon monoxide also produces a direct cytotoxic effect by inactivating some intracellular respiratory enzymes, but the relative importance of these various mechanisms often remains uncertain, particularly with regard to the lesions in the brain and myocardium.
一氧化碳是法医实践中最常见的有毒物质之一，其影响早已为人所知，但它与血红蛋白血红素辅基的结合性质直到最近才得以阐明。除了降低血液的携氧能力并导致全身性缺氧外，一氧化碳还会干扰氧合血红蛋白的解离和二氧化碳的清除。一氧化碳还通过使一些细胞内呼吸酶失活产生直接的细胞毒性作用，但这些不同机制的相对重要性往往仍不确定，尤其是在脑和心肌损伤方面。
