Havekes L M, van Vlijmen B J, Jong M C, van Dijk K W, Hofker M H
TNO-PG, Gaubius Laboratory, Leiden, The Netherlands.
Prostaglandins Leukot Essent Fatty Acids. 1997 Oct;57(4-5):463-6. doi: 10.1016/s0952-3278(97)90429-4.
In APOE*3-Leiden transgenic mice the atherosclerotic lesion size is correlated with plasma cholesterol. In these mice the plasma lipid levels are positively correlated with the relative amount of APOE 3-Leiden protein on the VLDL particle. The plasma cholesterol levels are influenced by diet, age and gender, mainly due to an effect of these factors on VLDL production rate. Excess of APOC1 protein does inhibit the hepatic clearance of VLDL remnant particles, whereas excess of apoE leads to a hampered extra-hepatic lipolysis of VLDL triglyceride.
在APOE*3-莱顿转基因小鼠中，动脉粥样硬化病变大小与血浆胆固醇相关。在这些小鼠中，血浆脂质水平与VLDL颗粒上APOE 3-莱顿蛋白的相对量呈正相关。血浆胆固醇水平受饮食、年龄和性别的影响，主要是因为这些因素对VLDL生成率有作用。APOC1蛋白过量确实会抑制VLDL残余颗粒的肝脏清除，而载脂蛋白E过量会导致VLDL甘油三酯的肝外脂解受阻。
