Monckton G, Marusyk H
Neurology. 1976 Mar;26(3):234-7. doi: 10.1212/wnl.26.3.234.
A study of the incorporation of hydrogen 3 (3H) leucine into skeletal muscle in patients with human muscular dystrophy and motor neuron disease showed uptake in cytoplasm and myofibrils. The techniques used were light and electron microscopy and autoradiography before and after glycerination (Szent-Gyorgyi). The results indicated an increase of 3H leucine uptake into cytoplasm of the dystrophic muscle and a marked drop in incorporation into structural protein. In the patients with motor neuron disease, the normal incorporation into cytoplasm was seen, with reduced uptake into structural protein. These results showed a different protein synthesis pattern in dystrophic and denervated muscle.
一项关于3氢（3H）亮氨酸掺入人类肌肉萎缩症和运动神经元疾病患者骨骼肌的研究表明，其在细胞质和肌原纤维中被摄取。所使用的技术包括光镜和电镜以及甘油处理前后的放射自显影术（ Szent - Gyorgyi法）。结果显示，萎缩性肌肉细胞质中3H亮氨酸摄取增加，而掺入结构蛋白的量显著下降。在运动神经元疾病患者中，观察到细胞质中的掺入正常，但结构蛋白摄取减少。这些结果表明萎缩性肌肉和失神经肌肉中存在不同的蛋白质合成模式。
