3-甲基组氨酸排泄作为神经肌肉疾病中肌原纤维蛋白分解代谢的指标。
3-Methylhistidine excretion as an index of myofibrillar protein catabolism in neuromuscular disease.
作者信息
McKeran R O, Halliday D, Purkiss P, Royston P
出版信息
J Neurol Neurosurg Psychiatry. 1979 Jun;42(6):536-41. doi: 10.1136/jnnp.42.6.536.
Abstract
Myofibrillar protein catabolism has been calculated in a variety of neuromuscular diseases from the amount of 3-methylhistidine excreted in the urine. It was found to be significantly raised in Duchenne type muscular dystrophy, motor neurone disease, polymyositis, and thyrotoxic myopathy. In Becker type muscular dystrophy the level was slightly raised. It was normal in scapuloperoneal and limb girdle dystrophy, dystrophia myotonica, extrapyramidal disease, and multiple sclerosis. It was significantly decreased in hypothyroid myopathy.
摘要
通过测定尿中3-甲基组氨酸的排泄量，已计算出多种神经肌肉疾病中的肌原纤维蛋白分解代谢情况。结果发现，在杜兴型肌营养不良症、运动神经元病、多发性肌炎和甲状腺毒症性肌病中，其水平显著升高。在贝克型肌营养不良症中，该水平略有升高。在肩胛带型和肢带型肌营养不良症、强直性肌营养不良症、锥体外系疾病和多发性硬化症中，其水平正常。在甲状腺功能减退性肌病中，该水平显著降低。
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