Kearney M T, Stubbs T A, Cowley A J, Macdonald I A
Department of Physiology and Pharmacology, Queens' Medical Centre, Nottingham, UK.
Clin Auton Res. 1997 Dec;7(6):285-91. doi: 10.1007/BF02267719.
The cardiovascular (CV) responses to meal ingestion and orthostasis are well established. The effect of meal ingestion and meal composition on the CV responses to orthostasis are unknown. The effect of high carbohydrate (HC) and high fat (HF) meal ingestion on the CV responses to simulated orthostatic stress (using graded lower body subatmospheric pressure (LBSP)) was assessed in nine healthy young volunteers. Cardiac output (CO), forearm blood flow (FABF) heart rate (HR) and blood pressure (BP) were measured before and during LBSP while fasted and after eating HC and HF meals. Ingestion of both meals led to an increase in CO and HR. Both meals resulted in a fall in total peripheral resistance but only HC led to a significant fall in BP (p < 0.05). HF had no effect on the CV responses to LBSP, whereas HC resulted in attenuated FABF and forearm vascular resistance responses (p < 0.05). Thus, ingestion of an HC meal significantly attenuates the forearm vascular response to orthostatic stress and the hypotensive effect of orthostasis is additive to that occurring after an HC meal.
心血管（CV）对进餐摄入和直立姿势的反应已得到充分证实。进餐摄入和膳食成分对直立姿势的心血管反应的影响尚不清楚。在九名健康年轻志愿者中评估了高碳水化合物（HC）和高脂肪（HF）餐摄入对模拟直立应激（使用分级下体负压（LBSP））的心血管反应的影响。在禁食期间、进食HC和HF餐之后，于LBSP之前和期间测量心输出量（CO）、前臂血流量（FABF）、心率（HR）和血压（BP）。两种餐的摄入均导致CO和HR增加。两种餐均导致总外周阻力下降，但只有HC导致BP显著下降（p<0.05）。HF对LBSP的心血管反应没有影响，而HC导致FABF和前臂血管阻力反应减弱（p<0.05）。因此，摄入HC餐会显著减弱前臂血管对直立应激的反应，并且直立姿势的降压作用与HC餐后出现的降压作用相加。
