Collins K J, Exton-Smith A N, James M H, Oliver D J
Age Ageing. 1980 Feb;9(1):17-24. doi: 10.1093/ageing/9.1.17.
The effects of ageing on autonomic nervous responses have been investigated in 29 young adults, 64 healthy elderly in the age range 66 to 86 years, and 20 elderly in-patients with hypothermia, instability of bladder function or marked orthostatic hypotension. In the healthy elderly group, the beat-to-beat variation in response to postural change was significantly diminished, the vasoconstrictor response to cooling reduced and baroreflex sensitivity during lower-body negative pressure was decreased compared with young adults. Patients with an atronic bladder, determined by urodynamic tests, showed an even more marked decrease in baroreflex sensitivity. The multisystem nature of these autonomic disturbances suggests that physiological impairment may occur in autonomic neural pathways with ageing.
对29名年轻成年人、64名年龄在66至86岁之间的健康老年人以及20名患有体温过低、膀胱功能不稳定或明显体位性低血压的老年住院患者，研究了衰老对自主神经反应的影响。与年轻成年人相比，在健康老年组中，对姿势变化的逐搏变化显著减小，对降温的血管收缩反应降低，下体负压期间的压力反射敏感性降低。通过尿动力学测试确定为无张力膀胱的患者，其压力反射敏感性下降更为明显。这些自主神经紊乱的多系统性质表明，随着年龄增长，自主神经通路可能会出现生理损伤。
