Crémieux A C, Carbon C
Hôpital Bichat-Claude Bernard, Paris, France.
Clin Infect Dis. 1997 Dec;25(6):1295-302. doi: 10.1086/516135.
Bone and joint infections are difficult to cure. The difficulty is related to the presence of bacteria adherent to foreign material in many cases and also to the limited activity of antibiotics in infected bones. Clinical trials are difficult to design because of the heterogeneity of the disease and the number of factors that could influence the therapeutic response. To control for these multiple variables, attempts have been made to develop reliable animal models of osteomyelitis and prosthetic joint infections that closely mimic the different infections seen in orthopedic surgery and that allow evaluation of the efficacy of surgical procedures as well as local or systemic antibiotic therapy. These models will continue to provide us information on the pathogenesis and management of such infections.
骨与关节感染难以治愈。这种困难在很多情况下与附着于异物的细菌的存在有关，也与抗生素在感染骨中的活性有限有关。由于该疾病的异质性以及可能影响治疗反应的因素数量众多，临床试验难以设计。为了控制这些多个变量，人们已尝试开发可靠的骨髓炎和人工关节感染动物模型，这些模型能紧密模拟骨科手术中所见的不同感染情况，并能评估手术程序以及局部或全身抗生素治疗的疗效。这些模型将继续为我们提供有关此类感染的发病机制和管理的信息。
