Norden C W
Department of Medicine, Montefiore Hospital, University of Pittsburgh School of Medicine, Pennsylvania 15213.
Rev Infect Dis. 1988 Jan-Feb;10(1):103-10. doi: 10.1093/clinids/10.1.103.
Because of the marked variability in presentation and management of osteomyelitis in patients, research with animal models that mimic the human disease offers a more controlled approach. Presently available animal models have been used to study pathogenesis, diagnosis, and treatment of osteomyelitis. Each model has advantages and disadvantages. Although it seems improbable that an ideal model of osteomyelitis will be achieved in the near future, further efforts to develop new experimental models and innovative research with present models are clearly needed.
由于骨髓炎患者的临床表现和治疗方法存在显著差异，利用模拟人类疾病的动物模型进行研究提供了一种更可控的方法。目前可用的动物模型已被用于研究骨髓炎的发病机制、诊断和治疗。每种模型都有其优缺点。虽然在不久的将来似乎不太可能实现理想的骨髓炎模型，但显然需要进一步努力开发新的实验模型，并对现有模型进行创新性研究。
