Széliga M E, Lamas M C, Lillo D A, Bregni C
Dpto. Tecnología Farmacéutica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
Boll Chim Farm. 1997 Jul-Aug;136(7):527-32.
The dissolution and diffussion methods through homogeneous synthetic membrane were studied in different semisolid topical formulations containing metronidazole and doxepin. The results suggest that the rate of release showed a first order kinetic for one of the formulations and the rate of release described by Higuchi for the others.
在含有甲硝唑和多塞平的不同半固体局部用制剂中，研究了通过均质合成膜的溶解和扩散方法。结果表明，其中一种制剂的释放速率呈现一级动力学，而其他制剂的释放速率则由Higuchi方程描述。
