[甲硝唑和多塞平在半固体制剂中透过合成膜的扩散与溶解]
[The diffusion and dissolution of metronidazole and doxepin in semisolid pharmaceutical forms through synthetic membranes].
作者信息
Széliga M E, Lamas M C, Lillo D A, Bregni C
机构信息
Dpto. Tecnología Farmacéutica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
出版信息
Boll Chim Farm. 1997 Jul-Aug;136(7):527-32.
PMID:9432192
Abstract
The dissolution and diffussion methods through homogeneous synthetic membrane were studied in different semisolid topical formulations containing metronidazole and doxepin. The results suggest that the rate of release showed a first order kinetic for one of the formulations and the rate of release described by Higuchi for the others.
摘要
在含有甲硝唑和多塞平的不同半固体局部用制剂中，研究了通过均质合成膜的溶解和扩散方法。结果表明，其中一种制剂的释放速率呈现一级动力学，而其他制剂的释放速率则由Higuchi方程描述。
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