Kovalev I E, Rubtsova E R
Farmakol Toksikol. 1976 Jan-Feb;39(1):119-23.
In mice of diverse lineages it is shown that 6-mercaptopurine and imuran, when used after a 3-day administration of phenobarbital, stimulate the formation of rosulae in the spleen of the animals immunized with sheep erythrocytes without raising the tires of the circulating hemolysins and hemagglutinins. In these conditions phenobarbital itself did not affect the immune responses. Upon preliminary introduction of phenobarbital the toxicity of imuran and 6-mercaptopurine for mice declined.
在不同品系的小鼠中发现，在用苯巴比妥给药3天后使用6-巯基嘌呤和硫唑嘌呤，可刺激用绵羊红细胞免疫的动物脾脏中玫瑰花结的形成，而不会提高循环溶血素和血凝素的滴度。在这些条件下，苯巴比妥本身不影响免疫反应。预先给予苯巴比妥后，硫唑嘌呤和6-巯基嘌呤对小鼠的毒性降低。
