[Weakening by means of phenobarbital of the immunodepressive and toxic effects of 6-mercaptopurine and imuran].

In mice of diverse lineages it is shown that 6-mercaptopurine and imuran, when used after a 3-day administration of phenobarbital, stimulate the formation of rosulae in the spleen of the animals immunized with sheep erythrocytes without raising the tires of the circulating hemolysins and hemagglutinins. In these conditions phenobarbital itself did not affect the immune responses. Upon preliminary introduction of phenobarbital the toxicity of imuran and 6-mercaptopurine for mice declined.