Kovalev I E, Rubtsova E R, Shaĭdrov V V
Vopr Onkol. 1976;22(6):71-5.
In the experiments on mice, immunized by mutton erythrocytes, the authors have studied the effect of phenobarbital, in the doses activating drug-metabolizing hepatic systems, on immunodepressive action of imurane, 6-mercaptopurine and cyclophosphane. It has been found that phenobarbital eliminates the immunodepression and reduces considerably the toxicity of the mentioned cytostatics. Under these conditions imurane and 6-mercaptopurine in certain doses render an immunostimulative instead of immunodepressive effect.
在以羊红细胞免疫的小鼠实验中，作者研究了苯巴比妥在激活肝脏药物代谢系统的剂量下，对硫唑嘌呤、6-巯基嘌呤和环磷酰胺免疫抑制作用的影响。已发现苯巴比妥可消除免疫抑制，并显著降低上述细胞抑制剂的毒性。在这些条件下，一定剂量的硫唑嘌呤和6-巯基嘌呤产生的是免疫刺激而非免疫抑制作用。
