在两个新西兰样本中，寻求新奇与4型多巴胺受体基因（DRD4）之间无关联。
No association between novelty seeking and the type 4 dopamine receptor gene (DRD4) in two New Zealand samples.
作者信息
Sullivan P F, Fifield W J, Kennedy M A, Mulder R T, Sellman J D, Joyce P R
机构信息
Virginia Commonwealth University/Medical College of Virginia, Richmond, USA.
出版信息
Am J Psychiatry. 1998 Jan;155(1):98-101. doi: 10.1176/ajp.155.1.98.
OBJECTIVE
In 1986 and 1987, Cloninger postulated the existence of the heritable behavioral trait of novelty seeking and its putative underpinnings in the dopaminergic systems of the ventral midbrain. Two widely reported studies found significant associations between novelty seeking and the type 4 dopamine receptor gene (DRD4), although a more recent study did not. The authors' objective was to investigate this association in two New Zealand samples.
METHOD
The authors studied two nonoverlapping samples: subjects in a depression treatment trial (N = 86) and subjects from 14 pedigrees dense with alcoholism (N = 181). DRD4 genotyping was based on a standard protocol.
RESULTS
Novelty seeking and DRD4 were not statistically associated.
CONCLUSIONS
In these samples, there was no suggestion that the DRD4 polymorphism contributed to individual differences in the behavioral trait of novelty seeking.
目的
1986年和1987年，克隆宁格假定存在寻求新奇的可遗传行为特征及其在腹侧中脑多巴胺能系统中的假定基础。两项广泛报道的研究发现寻求新奇与4型多巴胺受体基因（DRD4）之间存在显著关联，尽管最近的一项研究未发现此关联。作者的目的是在两个新西兰样本中研究这种关联。
方法
作者研究了两个不重叠的样本：一个抑郁症治疗试验中的受试者（N = 86）和来自14个酗酒高发家系的受试者（N = 181）。DRD4基因分型基于标准方案。
结果
寻求新奇与DRD4之间无统计学关联。
结论
在这些样本中，没有迹象表明DRD4多态性导致了寻求新奇行为特征的个体差异。
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