Kvien T K, Glennås A, Knudsrød O G, Smedstad L M, Mowinckel P, Førre O
Oslo City Dept. of Rheumatology, Diakonhjemmet Hospital, Norway.
Scand J Rheumatol. 1997;26(6):412-8. doi: 10.3109/03009749709065712.
The objective was (1) to examine the prevalence of rheumatoid arthritis (RA) by a county patient register, (2) to cross-validate the register findings by a postal population survey, and (3) to estimate prevalences of disease subsets according to age, sex, and levels of physical disability. The study was performed within a county setting in the city of Oslo with 356,486 inhabitants between 20 and 79 years of age. Prevalence estimates were calculated from a county patient register comprising 1333 patients with RA and a population survey of 10,000 inhabitants. The overall prevalence of RA between 20 and 79 years was 0.437 (95% CI 0.413, 0.461) after adjusting for the incompleteness of the register by a factor of 1.17. Prevalences exceeding 1.0% was only found among females over 60 years. The prevalence of RA with MHAQ scores > or = 1.5 and > or = 2.0 (range 1-4) was 0.225 (95% CI 0.209, 0.243) and 0.099 (0.088, 0.111) respectively. We conclude that RA is less frequent in the city of Oslo than stated in most of the literature. The prevalence of RA with physical disability levels assumed to be associated with increased mortality is less than half of the overall prevalence of 0.4-0.5%.
（1）通过县级患者登记册调查类风湿关节炎（RA）的患病率；（2）通过邮政人口调查对登记册结果进行交叉验证；（3）根据年龄、性别和身体残疾程度估算疾病亚组的患病率。该研究在奥斯陆市的一个县开展，研究对象为年龄在20至79岁之间的356,486名居民。患病率估计值通过一个包含1333例RA患者的县级患者登记册以及一项针对10,000名居民的人口调查计算得出。在通过1.17的系数对登记册的不完整性进行校正后，20至79岁人群中RA的总体患病率为0.437（95%可信区间0.413, 0.461）。仅在60岁以上女性中发现患病率超过1.0%。MHAQ评分≥1.5和≥2.0（范围1 - 4）的RA患病率分别为0.225（95%可信区间0.209, 0.243）和0.099（0.088, 0.111）。我们得出结论，奥斯陆市RA的发病率低于大多数文献所述。假定与死亡率增加相关的身体残疾水平的RA患病率不到总体患病率0.4 - 0.5%的一半。
