Regulation of neurons and astrocytes by thrombin and protease nexin-1. Relationship to brain injury.

作者信息

Cunningham D D, Donovan F M

机构信息

Department of Microbiology and Molecular Genetics, College of Medicine, University of California, Irvine 92697-4025, USA.

出版信息

Adv Exp Med Biol. 1997;425:67-75. doi: 10.1007/978-1-4615-5391-5_7.

DOI:10.1007/978-1-4615-5391-5_7

PMID:9433490

Abstract

摘要

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Regulation of neurons and astrocytes by thrombin and protease nexin-1. Relationship to brain injury.

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Inhibitory mechanism of serpins. Interaction of thrombin with antithrombin and protease nexin 1.丝氨酸蛋白酶抑制剂的抑制机制。凝血酶与抗凝血酶及蛋白酶连接蛋白1的相互作用。

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Role of glial-derived nexin in neuronal differentiation and in acute brain injury and potential involvement in exacerbation of neurodegeneration in Alzheimer's disease.神经胶质衍生的神经蛋白酶在神经元分化、急性脑损伤中的作用以及在阿尔茨海默病神经退行性变加重过程中的潜在参与情况。

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Cells regulate their mitogenic response to thrombin through release of protease nexin.细胞通过释放蛋白酶nexin来调节其对凝血酶的促有丝分裂反应。

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Neuroserpin is expressed in the pituitary and adrenal glands and induces the extension of neurite-like processes in AtT-20 cells.神经丝氨酸蛋白酶抑制剂在垂体和肾上腺中表达，并诱导AtT - 20细胞中神经突样突起的延伸。

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