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Bipolar disorder and chromosome 18: an analysis of multiple data sets.

作者信息

Badner J A, Goldin L R

机构信息

National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.

出版信息

Genet Epidemiol. 1997;14(6):569-74. doi: 10.1002/(SICI)1098-2272(1997)14:6<569::AID-GEPI3>3.0.CO;2-V.

DOI:10.1002/(SICI)1098-2272(1997)14:6<569::AID-GEPI3>3.0.CO;2-V
PMID:9433544
Abstract

There have been conflicting reports of linkage between bipolar disorder and chromosome 18. We have analyzed five separate data sets using the two-point affected sib-pair method and family based association methods. We have found evidence of linkage in multiple data sets and differences in maternal and paternal allele sharing. Suggestive, though nonsignificant, evidence of linkage disequilibrium of two tightly linked markers has also been demonstrated in multiple data sets.

摘要

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