Davis S, Sobel E, Marinov M, Weeks D E
Department of Human Genetics, University of Pittsburgh, Pennsylvania 15261, USA.
Genet Epidemiol. 1997;14(6):605-10. doi: 10.1002/(SICI)1098-2272(1997)14:6<605::AID-GEPI9>3.0.CO;2-Y.
We have analyzed the GAW10 data from several studies of bipolar affective disorder (BPAD) using the software packages SimIBD and SIMWALK2. SimIBD implements a simulation-based affected-pedigree-member (APM) statistic, called SimAPM, as well as an APM-like statistic, also called SimIBD, that measures identical-by-descent (IBD) sharing. SIMWALK2 uses Markov chain Monte Carlo techniques to compute several IBD-based statistics on the degree of marker-allele clustering among all affected relatives. We have found no strong evidence of linkage to either chromosome 5 or 18. However, we did find that several markers showed p-values less than 0.01 and may deserve further study.
我们使用软件包SimIBD和SIMWALK2分析了来自多项双相情感障碍（BPAD）研究的GAW10数据。SimIBD实现了一种基于模拟的患病家系成员（APM）统计量，称为SimAPM，以及一种类似APM的统计量，也称为SimIBD，用于测量同源相同（IBD）共享情况。SIMWALK2使用马尔可夫链蒙特卡罗技术来计算所有患病亲属中标记等位基因聚类程度的几个基于IBD的统计量。我们没有发现与5号或18号染色体存在强连锁的有力证据。然而，我们确实发现几个标记的p值小于0.01，可能值得进一步研究。
