S.A.G.E. SIBPAL比例-IBD的后验p值与ACTHR112的Haseman-Elston统计量的关联
Association of posterior p-values of S.A.G.E. SIBPAL proportion-IBD and Haseman-Elston statistics for ACTHR112.
作者信息
Gordon D, Finch S J, Jacobs A L, Mendell N R, Single R M, Marr T G
机构信息
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
出版信息
Genet Epidemiol. 1997;14(6):629-34. doi: 10.1002/(SICI)1098-2272(1997)14:6<629::AID-GEPI13>3.0.CO;2-S.
A common practice among researchers performing linkage studies is the use of equal allele frequencies as input when reporting p-values from computer linkage programs such as S.A.G.E. SIBPAL. Our results, using 5,000 sets from a uniform-prior distribution of allele frequencies, showed that such input may be problematic. Further, we found that the S.A.G.E. SIBPAL test for proportion of alleles shared identical by descent among concordantly affected sib pairs showed a greater percentage of significant p-values with decreasing parental genotype information (Table III), while the S.A.G.E. SIBPAL Haseman-Elston test produced significant p-values comparatively less frequently (Table IV).
进行连锁研究的研究人员的一个常见做法是，在报告来自诸如S.A.G.E. SIBPAL等计算机连锁程序的p值时，使用相等的等位基因频率作为输入。我们使用来自等位基因频率均匀先验分布的5000组数据得出的结果表明，这种输入可能存在问题。此外，我们发现，对于受影响一致的同胞对中通过血缘共享相同等位基因的比例，S.A.G.E. SIBPAL检验显示，随着亲本基因型信息的减少，显著p值的百分比更高（表III），而S.A.G.E. SIBPAL哈斯曼-埃尔斯顿检验产生显著p值的频率相对较低（表IV）。
Zotero 插件