Ludwig H
Geburtshilfe Frauenheilkd. 1976 Feb;36(2):97-108.
Already in 1909 methods of an intrauterine contraception were indicated in Germany. Their practical use was intiated twenty years later by Ernst Graefenberg. Further development almost exclusively takes place in the USA, whereas the major part of basic investigations has been done. The introduction of copper bearing IUD's undoubtedly increased the safety of intrauterine contraception. Investigations concerning the morphology of the endometrial contact area (f.e. by SEM) and the evaluation of certain biochemical facts associated with the release of copper ions, lead to hypotheses of the mode of action. A randomized comparative study of CuT 200 verus Lippes Loop D demonstrates similar pregnancy rates with both types of IUD, but a moderate advantage of the CuT 200 in regard of the expulsion rate and the removal rates due to bleeding and/or pains. The author stresses that it might be medically indicated to terminate pregnancy when a woman has conceived in spite of a copper bearing IUD in situ. His statement is in correspondence to the recommendations of the Population Council, but nevertheless, this problem as yet is far of being solved unanimously. Most complications associated with the IUD are due to incorrect insertion. It is therefore postulated to insert the IUD menstrually, maintaining strictly sterile conditions, a non-deformed uterus being hooked on a bullet forceps. As already anticipated by Ludwig Fraenkel a careful insertion should be done by experienced doctors only, this fact counteracting the widespread use of this contraceptive method to be in the second place as compared to hormonal contraception.
早在1909年,德国就已指出宫内避孕的方法。20年后,恩斯特·格雷芬伯格开始将其实际应用。进一步的发展几乎完全在美国进行,而大部分基础研究也是在美国完成的。含铜宫内节育器的引入无疑提高了宫内避孕的安全性。关于子宫内膜接触区域形态学的研究(例如通过扫描电子显微镜)以及对与铜离子释放相关的某些生化事实的评估,引发了对作用方式的假设。一项关于CuT 200与利普斯环D的随机对照研究表明,两种类型的宫内节育器的妊娠率相似,但在排出率以及因出血和/或疼痛导致的取出率方面,CuT 200有一定优势。作者强调,尽管宫内有含铜节育器,若妇女仍怀孕,从医学角度可能需要终止妊娠。他的说法与人口理事会的建议一致,但即便如此,这个问题仍远未得到一致解决。与宫内节育器相关的大多数并发症是由于插入不当。因此,假定应在月经期插入宫内节育器,严格保持无菌条件,用子弹镊钩住未变形的子宫。正如路德维希·弗伦克尔早已预见的那样,应由经验丰富的医生进行仔细插入,这一事实使得这种避孕方法的广泛使用与激素避孕相比位居第二。