Pichard C, Kyle U G, Janssens J P, Burdet L, Rochat T, Slosman D O, Fitting J W, Thiebaud D, Roulet M, Tschopp J M, Landry M, Schutz Y
Division of Clinical Nutrition and Dietetics, University Hospital, Geneva, Switzerland.
Nutrition. 1997 Nov-Dec;13(11-12):952-8. doi: 10.1016/s0899-9007(97)00336-5.
Nutrition assessment is important during chronic respiratory insufficiency to evaluate the level of malnutrition or obesity and should include body composition measurements. The appreciation of fat-free and fat reserves in patients with chronic respiratory insufficiency can aid in designing an adapted nutritional support, e.g., nutritional support in malnutrition and food restriction in obesity. The purpose of the present study was to cross-validate fat-free and fat mass obtained by various bioelectric impedance (BIA) formulas with the fat-free and fat mass measured by dual-energy X-ray absorptiometry (DXA) and determine the formulas that are best suited to predict the fat-free and fat mass for a group of patients with severe chronic respiratory insufficiency. Seventy-five patients (15 women and 60 men) with chronic obstructive and restrictive respiratory insufficiency aged 45-86 y were included in this study. Body composition was calculated according to 13 different BIA formulas for women and 12 for men and compared with DXA. Because of the variability, calculated as 2 standard deviations, of +/- 5.0 kg fat-free mass for women and +/- 6.4 kg for men for the best predictive formula, the use of the various existing BIA formulas was considered not clinically relevant. Therefore disease-specific formulas for patients with chronic respiratory insufficiency should be developed to improve the prediction of fat-free and fat mass by BIA in these patients.
在慢性呼吸功能不全期间，营养评估对于评估营养不良或肥胖程度很重要，且应包括身体成分测量。了解慢性呼吸功能不全患者的去脂体重和脂肪储备有助于设计适应性营养支持方案，例如，对营养不良患者进行营养支持，对肥胖患者进行饮食限制。本研究的目的是将通过各种生物电阻抗（BIA）公式获得的去脂体重和脂肪量与通过双能X线吸收法（DXA）测量的去脂体重和脂肪量进行交叉验证，并确定最适合预测一组严重慢性呼吸功能不全患者去脂体重和脂肪量的公式。本研究纳入了75例年龄在45 - 86岁之间的慢性阻塞性和限制性呼吸功能不全患者（15名女性和60名男性）。根据13种不同的女性BIA公式和12种男性BIA公式计算身体成分，并与DXA结果进行比较。由于最佳预测公式计算得出的女性去脂体重标准差为±5.0 kg、男性为±6.4 kg，存在变异性，因此认为使用现有的各种BIA公式在临床上不具有相关性。因此，应开发针对慢性呼吸功能不全患者的特定疾病公式，以改善BIA对这些患者去脂体重和脂肪量的预测。
