肥胖对慢性呼吸道疾病的影响：病理生理学与治疗策略
The effect of obesity on chronic respiratory diseases: pathophysiology and therapeutic strategies.
作者信息
Poulain Magali, Doucet Mariève, Major Geneviève C, Drapeau Vicky, Sériès Frédéric, Boulet Louis-Philippe, Tremblay Angelo, Maltais François
机构信息
Division de kinésiologie, Département de médecine sociale et préventive, Université Laval, Québec, Qué.
出版信息
CMAJ. 2006 Apr 25;174(9):1293-9. doi: 10.1503/cmaj.051299.
Abstract
Sedentary lifestyles and increased pollution brought about by industrialization pose major challenges to the prevention of both obesity and chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, obstructive sleep apnea and obesity hypoventilation syndrome. Obesity has emerged as an important risk factor for these respiratory diseases, and in many instances weight loss is associated with important symptomatic improvement. Moreover, obesity may influence the development and presentation of these diseases. In this article, we review the current understanding of the influence of obesity on chronic respiratory diseases and the clinical management of obesity concurrent with asthma, COPD, obstructive sleep apnea or obesity hypoventilation syndrome.
摘要
久坐不动的生活方式以及工业化带来的污染加剧，给肥胖症和慢性呼吸道疾病（如慢性阻塞性肺疾病、哮喘、阻塞性睡眠呼吸暂停和肥胖低通气综合征）的预防带来了重大挑战。肥胖已成为这些呼吸道疾病的重要危险因素，在许多情况下，体重减轻与症状的显著改善相关。此外，肥胖可能会影响这些疾病的发生和表现。在本文中，我们综述了目前对肥胖对慢性呼吸道疾病影响的认识，以及合并哮喘、慢性阻塞性肺疾病、阻塞性睡眠呼吸暂停或肥胖低通气综合征的肥胖症的临床管理。
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本文引用的文献
1
Body mass, fat-free body mass, and prognosis in patients with chronic obstructive pulmonary disease from a random population sample: findings from the Copenhagen City Heart Study.来自随机人群样本的慢性阻塞性肺疾病患者的体重、去脂体重与预后：哥本哈根城市心脏研究的结果
Am J Respir Crit Care Med. 2006 Jan 1;173(1):79-83. doi: 10.1164/rccm.200506-969OC.
2
Are overweight asthmatics more difficult to control?超重的哮喘患者是否更难控制病情？
Allergy. 2006 Jan;61(1):79-84. doi: 10.1111/j.1398-9995.2005.00953.x.
3
Deep inspiration avoidance and airway response to methacholine: Influence of body mass index.
Can Respir J. 2005 Oct;12(7):371-6. doi: 10.1155/2005/517548.
4
Obstructive sleep apnea as a risk factor for stroke and death.阻塞性睡眠呼吸暂停作为中风和死亡的危险因素。
N Engl J Med. 2005 Nov 10;353(19):2034-41. doi: 10.1056/NEJMoa043104.
5
Systemic effects of chronic obstructive pulmonary disease.慢性阻塞性肺疾病的全身影响
Proc Am Thorac Soc. 2005;2(4):367-70; discussion 371-2. doi: 10.1513/pats.200504-026SR.
6
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7
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8
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9
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10
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