Falkner D, Wilson J, Medsger T A, Morel P A
University of Pittsburgh Cancer Institute, Pennsylvania 15213, USA.
Arthritis Rheum. 1998 Jan;41(1):74-80. doi: 10.1002/1529-0131(199801)41:1<74::AID-ART10>3.0.CO;2-C.
To determine the clinical and immunogenetic features of systemic sclerosis (SSc) patients with anti-Th/To autoantibodies.
HLA class II alleles were determined by DNA oligotyping in a large group of SSc patients with anticentromere antibodies (ACA), anti-topoisomerase I (anti-topo I), and anti-Th/To autoantibodies.
Clinical features of the 28 anti-Th/To-positive SSc patients were similar to those observed in the 56 ACA-positive SSc patients, except for a decreased frequency of gastrointestinal involvement in anti-Th/To-positive patients. Immunogenetic analysis revealed a significant increase in the frequency of HLA-DR11 in the anti-Th/To-positive and the anti-topo I-positive patients. The anti-Th/To-positive patients also had a significant reduction in the frequency of HLA-DR7, similar to that seen in ACA-positive SSc patients.
Despite clinical and immunogenetic similarities with both the ACA- and anti-topo I-positive patients, anti-Th/To-positive SSc patients present a characteristic pattern of clinical and immunogenetic features that may have implications regarding etiology, pathogenesis, and treatment.
确定抗Th/To自身抗体阳性的系统性硬化症（SSc）患者的临床和免疫遗传学特征。
通过DNA寡核苷酸分型法对一大组抗着丝点抗体（ACA）阳性、抗拓扑异构酶I（抗topo I）阳性及抗Th/To自身抗体阳性的SSc患者进行HLA II类等位基因检测。
28例抗Th/To阳性的SSc患者的临床特征与56例ACA阳性的SSc患者相似，但抗Th/To阳性患者胃肠道受累频率较低。免疫遗传学分析显示，抗Th/To阳性和抗topo I阳性患者中HLA-DR11频率显著增加。抗Th/To阳性患者的HLA-DR7频率也显著降低，与ACA阳性的SSc患者相似。
尽管抗Th/To阳性的SSc患者在临床和免疫遗传学方面与ACA阳性及抗topo I阳性患者存在相似之处，但他们呈现出独特的临床和免疫遗传学特征模式，这可能对病因、发病机制及治疗具有重要意义。
