Kayser O, Kolodziej H
Institut für Pharmazie II, Pharmazeutische Biologie, Freie Universität Berlin, Germany.
Planta Med. 1997 Dec;63(6):508-10. doi: 10.1055/s-2006-957752.
The antibacterial activity of extracts and isolated constituents (scopoletin, umckalin, 5,6,7-trimethoxycoumarin, 6,8-dihydroxy-5,7-dimethoxycoumarin, (+)-catechin, gallic acid and its methyl ester) of Pelargonium sidoides and Pelargonium reniforme (Geraniaceae), plant species used in folk medicine by the Southern African native population, was evaluated against 8 microorganisms, including 3 Gram-positive (Staphylococcus aureus, Streptococcus pneumoniae, and beta-hemolytic Streptococcus 1451) and 5 Gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Haemophilus influenzae). Minimum inhibitory concentrations (MICs) varied with the preparation of the extracts and microorganisms tested, from about 0.6 mg/ml for aqueous phases to over 10 mg/ml for crude Pelargonium extracts. With the exception of the ineffective (+)-catechin, all the potentially active compounds exhibited antibacterial activities with MICs of 200-1000 micrograms/ml. The results provide for a rational basis of the traditional use of the titled Pelargonium species.
对南非当地居民用于民间医学的天竺葵属植物（牻牛儿苗科）中的矮天竺葵和肾叶天竺葵的提取物及分离成分（东莨菪素、没卡林、5,6,7-三甲氧基香豆素、6,8-二羟基-5,7-二甲氧基香豆素、(+)-儿茶素、没食子酸及其甲酯）的抗菌活性进行了评估，受试微生物包括8种，其中有3种革兰氏阳性菌（金黄色葡萄球菌、肺炎链球菌和β-溶血性链球菌1451）以及5种革兰氏阴性菌（大肠杆菌、肺炎克雷伯菌、奇异变形杆菌、铜绿假单胞菌、流感嗜血杆菌）。最低抑菌浓度（MIC）因提取物的制备方法和受试微生物的不同而有所变化，水相提取物的MIC约为0.6毫克/毫升，天竺葵粗提取物的MIC则超过10毫克/毫升。除无效的(+)-儿茶素外，所有潜在活性化合物均表现出抗菌活性，其MIC为200 - 1000微克/毫升。这些结果为上述天竺葵属植物的传统用途提供了合理依据。
